The Biggest Problems
We Must Solve

Rising global temperatures from greenhouse gas emissions are disrupting weather patterns, raising sea levels, and threatening ecos…

Creating artificial general intelligence that matches or exceeds human capabilities across all cognitive tasks, while ensuring it …

Alzheimer's and other neurodegenerative diseases affect over 55 million people worldwide. No disease-modifying treatment exists. W…

Harnessing the energy that powers stars — fusing hydrogen isotopes to produce clean, abundant, carbon-free electricity with no lon…

Developing methods to detect and communicate with potential extraterrestrial civilizations. The Fermi Paradox asks: where is every…

Treating aging as a treatable medical condition rather than an inevitable decline. Targeting the root causes of aging to extend bo…

Establishing self-sustaining human colonies on Mars — making humanity multi-planetary. A backup civilization in case of Earth-leve…

Quantum computers that can solve practically useful problems — drug discovery, materials design, optimization — that are intractab…

The hard problem of consciousness: why and how subjective experience arises from physical matter. We don't know how neurons firing…